CTCAE RápidoAdverse event grades · CTCAE v6.0
Código Onco

Nervous system disorders

The 71 CTCAE v6.0 adverse events in Nervous system disorders, with grades 1 to 5.

Abducens nerve disorder

Nervous system disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by dysfunction of the abducens nerve (sixth cranial nerve).

Navigational noteConsider Nervous system disorders: Peripheral motor neuropathy, Peripheral sensory neuropathy.

MedDRA code (LLT): 10053662 · CTCAE v6.0 (NCI), original English text.

Accessory nerve disorder

Nervous system disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by dysfunction of the accessory nerve (eleventh cranial nerve).

Navigational noteConsider Nervous system disorders: Peripheral motor neuropathy, Peripheral sensory neuropathy.

MedDRA code (LLT): 10060929 · CTCAE v6.0 (NCI), original English text.

Acoustic nerve disorder NOS

Nervous system disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by dysfunction of the acoustic nerve (eighth cranial nerve).

Navigational noteConsider Nervous system disorders: Peripheral motor neuropathy, Peripheral sensory neuropathy.

MedDRA code (LLT): 10000521 · CTCAE v6.0 (NCI), original English text.

Akathisia

Nervous system disorders
  1. G1Mild restlessness or increased motor activity
  2. G2Moderate restlessness or increased motor activity; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe restlessness or increased motor activity; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an uncomfortable feeling of inner restlessness and inability to stay still; this is a side effect of some psychotropic drugs.

MedDRA code (LLT): 10001540 · CTCAE v6.0 (NCI), original English text.

Amnesia

Nervous system disorders
  1. G1Mild; transient memory loss
  2. G2Moderate; short term memory loss; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe; long term memory loss; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by systematic and extensive loss of memory.

MedDRA code (LLT): 10001949 · CTCAE v6.0 (NCI), original English text.

Anosmia

Nervous system disorders
  1. G1Present
  2. G2Not applicable
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a change in the sense of smell.

Navigational noteConsider Nervous system disorders: Olfactory nerve disorder.

MedDRA code (LLT): 10002653 · CTCAE v6.0 (NCI), original English text.

Arachnoiditis

Nervous system disorders
  1. G1Mild symptoms
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by inflammation of the arachnoid membrane and adjacent subarachnoid space.

MedDRA code (LLT): 10003074 · CTCAE v6.0 (NCI), original English text.

Ataxia

Nervous system disorders
  1. G1Mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; mechanical assistance indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10003591 · CTCAE v6.0 (NCI), original English text.

Autonomic neuropathy

Nervous system disordersNew in v6.0
  1. G1Mild symptoms
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by damage to nerves that control your internal organs.

MedDRA code (LLT): 10061666 · CTCAE v6.0 (NCI), original English text.

Brachial plexopathy

Nervous system disorders
  1. G1Mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand.

MedDRA code (LLT): 10065417 · CTCAE v6.0 (NCI), original English text.

Brain fog

Nervous system disordersNew in v6.0
  1. G1Present
  2. G2Limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by thinking and memory problems that a patient with cancer may have during or after cancer treatment.

MedDRA code (LLT): 10088940 · CTCAE v6.0 (NCI), original English text.

Central nervous system necrosis

Nervous system disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; corticosteroids indicated
  3. G3Severe symptoms; medical intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a necrotic process occurring in the brain and/or spinal cord.

MedDRA code (LLT): 10065784 · CTCAE v6.0 (NCI), original English text.

Cerebral venous sinus thrombosis

Nervous system disordersNew in v6.0
  1. G1Not applicable
  2. G2Intervention not indicated
  3. G3Medical intervention indicated (e.g., anticoagulants)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a thrombus (blood clot) in the brain’s venous sinuses leading to swelling and bleeding.

MedDRA code (LLT): 10083037 · CTCAE v6.0 (NCI), original English text.

Cerebrospinal fluid leakage

Nervous system disorders
  1. G1Post-craniotomy: asymptomatic; post-lumbar puncture: transient headache; postural care indicated
  2. G2Post-craniotomy: moderate symptoms; medical intervention indicated; post-lumbar puncture: persistent moderate symptoms; blood patch indicated
  3. G3Severe symptoms; medical intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by loss of cerebrospinal fluid into the surrounding tissues.

MedDRA code (LLT): 10008164 · CTCAE v6.0 (NCI), original English text.

Cognitive disturbance

Nervous system disorders
  1. G1Mild cognitive disability; not interfering with work/school/life performance; specialized educational services/devices not indicated
  2. G2Moderate cognitive disability; interfering with work/school/life performance but capable of independent living; specialized resources on part time basis indicated
  3. G3Severe cognitive disability; significant impairment of work/school/life performance
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a conspicuous change in cognitive function.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10009845 · CTCAE v6.0 (NCI), original English text.

Concentration impairment

Nervous system disorders
  1. G1Mild inattention or decreased level of concentration
  2. G2Moderate impairment in attention or decreased level of concentration; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe impairment in attention or decreased level of concentration; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a deterioration in the ability to concentrate.

MedDRA code (LLT): 10010250 · CTCAE v6.0 (NCI), original English text.

Depressed level of consciousness

Nervous system disorders
  1. G1Decreased level of alertness
  2. G2Sedation; slow response to stimuli; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Difficult to arouse
  4. G4Life-threatening consequences; coma; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a decrease in ability to perceive and respond.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10012373 · CTCAE v6.0 (NCI), original English text.

Dizziness

Nervous system disorders
  1. G1Mild unsteadiness or sensation of movement
  2. G2Moderate unsteadiness or sensation of movement; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe unsteadiness or sensation of movement; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a disturbing sensation of lightheadedness, unsteadiness, giddiness, spinning or rocking.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10013573 · CTCAE v6.0 (NCI), original English text.

Dysarthria

Nervous system disorders
  1. G1Mild slurred speech
  2. G2Moderate impairment of articulation or slurred speech
  3. G3Severe impairment of articulation or slurred speech
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by slow and slurred speech resulting from an inability to coordinate the muscles used in speech.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10013887 · CTCAE v6.0 (NCI), original English text.

Dysesthesia

Nervous system disorders
  1. G1Mild sensory alteration
  2. G2Moderate sensory alteration; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe sensory alteration; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by distortion of sensory perception, resulting in an abnormal and unpleasant sensation.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10062872 · CTCAE v6.0 (NCI), original English text.

Dysgeusia

Nervous system disorders
  1. G1Altered taste but no change in diet
  2. G2Altered taste with change in diet (e.g., oral supplements); noxious or unpleasant taste; loss of taste
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by abnormal sensual experience with the taste of foodstuffs; it can be related to a decrease in the sense of smell.

MedDRA code (LLT): 10013911 · CTCAE v6.0 (NCI), original English text.

Dysphasia

Nervous system disorders
  1. G1Awareness of receptive or expressive characteristics; not impairing ability to communicate
  2. G2Moderate receptive or expressive characteristics; impairing ability to communicate spontaneously
  3. G3Severe receptive or expressive characteristics; impairing ability to read, write or communicate intelligibly
  4. G4Total loss of the ability to read, write, or communicate intelligibly
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by impairment of verbal communication skills, often resulting from brain damage.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10013951 · CTCAE v6.0 (NCI), original English text.

Edema cerebral

Nervous system disorders
  1. G1Radiographic finding only and no medical management initiated
  2. G2Not applicable
  3. G3New onset; worsening from baseline; initiation of steroid therapy
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by swelling due to an excessive accumulation of fluid in the brain.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10014217 · CTCAE v6.0 (NCI), original English text.

Encephalopathy

Nervous system disorders
  1. G1Mild symptoms
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a pathologic process involving the brain.

MedDRA code (LLT): 10014625 · CTCAE v6.0 (NCI), original English text.

Extrapyramidal disorder

Nervous system disorders
  1. G1Mild involuntary movements
  2. G2Moderate involuntary movements; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe involuntary movements or torticollis; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness.

MedDRA code (LLT): 10015832 · CTCAE v6.0 (NCI), original English text.

Facial muscle weakness

Nervous system disorders
  1. G1Mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a reduction in the strength of the facial muscles.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10051272 · CTCAE v6.0 (NCI), original English text.

Facial nerve disorder

Nervous system disorders
  1. G1Mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by dysfunction of the facial nerve (seventh cranial nerve).

MedDRA code (LLT): 10061457 · CTCAE v6.0 (NCI), original English text.

Glossopharyngeal nerve disorder

Nervous system disorders
  1. G1Mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by dysfunction of the glossopharyngeal nerve (ninth cranial nerve).

MedDRA code (LLT): 10061185 · CTCAE v6.0 (NCI), original English text.

Guillain-Barre syndrome

Nervous system disorders
  1. G1Mild symptoms
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated; intubation
  5. G5Death
Definition and note

DefinitionA disorder characterized by the body's immune system attacking the peripheral nervous system causing ascending paralysis.

MedDRA code (LLT): 10018767 · CTCAE v6.0 (NCI), original English text.

Headache

Nervous system disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a sensation of marked discomfort in various parts of the head, not confined to the area of distribution of any nerve.

MedDRA code (LLT): 10019211 · CTCAE v6.0 (NCI), original English text.

Hemiparesis

Nervous system disordersNew in v6.0
  1. G1Symptomatic; perceived by patient but not evident on physical exam
  2. G2Symptomatic; evident on physical exam; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a reduction in the strength of the muscles on one side of the body.

MedDRA code (LLT): 10019465 · CTCAE v6.0 (NCI), original English text.

Hydrocephalus

Nervous system disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; intervention not indicated
  3. G3Severe symptoms or neurological deficit; intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain.

MedDRA code (LLT): 10020508 · CTCAE v6.0 (NCI), original English text.

Hypersomnia

Nervous system disorders
  1. G1Mild increased need for sleep
  2. G2Moderate increased need for sleep
  3. G3Severe increased need for sleep
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by excessive sleepiness during the daytime.

MedDRA code (LLT): 10020765 · CTCAE v6.0 (NCI), original English text.

Hypoglossal nerve disorder

Nervous system disorders
  1. G1Mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by dysfunction of the hypoglossal nerve (twelfth cranial nerve).

MedDRA code (LLT): 10061212 · CTCAE v6.0 (NCI), original English text.

Immune effector cell-associated neurotoxicity syndrome

Nervous system disordersNew in v6.0
  1. G1Mild symptoms; Immune Effector Cell-Associated Encephalopathy (ICE) score 7 - 9; Cornell Assessment of Pediatric Delirium (CAPD) score 1 - 8 AND awakens spontaneously
  2. G2Moderate symptoms; ICE score 3 - 6; CAPD score 1 - 8 AND awakens to voice; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; ICE score 0 - 2; CAPD score >=9 AND awakens only to tactile stimulus; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a pathologic process involving the central nervous system following any immune therapy that results in the activation or engagement of endogenous or infused T cells and/or other immune effector cells. Symptoms or signs can be progressive and may include aphasia, altered level of consciousness, impairment of cognitive skills, motor weakness, seizures, and cerebral edema.

MedDRA code (LLT): 10083347 · CTCAE v6.0 (NCI), original English text.

Intracranial hemorrhage

Nervous system disorders
  1. G1Mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; intervention indicated
  3. G3Ventriculostomy, ICP monitoring, intraventricular thrombolysis, or invasive intervention indicated; hospitalization
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by bleeding from within the cranium.

MedDRA code (LLT): 10022763 · CTCAE v6.0 (NCI), original English text.

Lethargy

Nervous system disorders
  1. G1Mild symptoms; reduced alertness and awareness
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a decrease in consciousness characterized by mental and physical inertness.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10024264 · CTCAE v6.0 (NCI), original English text.

Leukoencephalopathy

Nervous system disorders
  1. G1Asymptomatic; small focal T2/FLAIR hyperintensities; involving periventricular white matter or <1/3 of susceptible areas of cerebrum +/- mild increase in subarachnoid space (SAS) and/or mild ventriculomegaly
  2. G2Moderate symptoms; focal T2/FLAIR hyperintensities, involving periventricular white matter extending into centrum semiovale or involving 1/3 to 2/3 of susceptible areas of cerebrum +/- moderate increase in SAS and/or moderate ventriculomegaly
  3. G3Severe symptoms; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving 2/3 or more of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly
  4. G4Life-threatening consequences; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving most of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly
  5. G5Death
Definition and note

DefinitionA disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.

MedDRA code (LLT): 10024382 · CTCAE v6.0 (NCI), original English text.

Memory impairment

Nervous system disorders
  1. G1Mild memory impairment
  2. G2Moderate memory impairment; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe memory impairment; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a deterioration in memory function.

MedDRA code (LLT): 10027175 · CTCAE v6.0 (NCI), original English text.

Meningismus

Nervous system disorders
  1. G1Mild symptoms
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges.

MedDRA code (LLT): 10027198 · CTCAE v6.0 (NCI), original English text.

Movements involuntary

Nervous system disorders
  1. G1Mild symptoms
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by uncontrolled and purposeless movements.

MedDRA code (LLT): 10028041 · CTCAE v6.0 (NCI), original English text.

Myasthenia gravis

Nervous system disorders
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by weakness and rapid fatigue of any of the skeletal muscles.

MedDRA code (LLT): 10028417 · CTCAE v6.0 (NCI), original English text.

Nervous system disorders - Other, specify

Nervous system disorders
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

MedDRA code (LLT): 10029205 · CTCAE v6.0 (NCI), original English text.

Neuralgia

Nervous system disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by intense painful sensation along a nerve or group of nerves.

MedDRA code (LLT): 10029223 · CTCAE v6.0 (NCI), original English text.

Nystagmus

Nervous system disorders
  1. G1Not applicable
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by involuntary movements of the eyeballs.

MedDRA code (LLT): 10029864 · CTCAE v6.0 (NCI), original English text.

Oculomotor nerve disorder

Nervous system disorders
  1. G1Mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by dysfunction of the oculomotor nerve (third cranial nerve).

MedDRA code (LLT): 10053661 · CTCAE v6.0 (NCI), original English text.

Olfactory nerve disorder

Nervous system disorders
  1. G1Not applicable
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by dysfunction of the olfactory nerve (first cranial nerve).

MedDRA code (LLT): 10056388 · CTCAE v6.0 (NCI), original English text.

Optic neuritis

Nervous system disordersNew in v6.0
  1. G1Asymptomatic or mild symptoms; only enhancement on MRI scan with no change in vision
  2. G2Treatment indicated; best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline in the affected eye; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe or medically significant but not immediately sight-threatening; decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200) in the affected eye; oral steroids indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Sight-threatening consequences; urgent intervention indicated; best corrected visual acuity of 20/200 or worse in the affected eye: significant visual field loss; marked optic disc edema or enhancement on MRI scan; intravenous steroids indicated; blindness
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by inflammation and demyelination of the optic nerve that causes acute, usually monocular, visual loss.

MedDRA code (LLT): 10030942 · CTCAE v6.0 (NCI), original English text.

Paresthesia

Nervous system disorders
  1. G1Mild symptoms
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by functional disturbances of sensory neurons resulting in abnormal cutaneous sensations of tingling, numbness, pressure, cold, and/or warmth.

Navigational noteConsider Nervous system disorders: Peripheral motor neuropathy, Peripheral sensory neuropathy.

MedDRA code (LLT): 10033987 · CTCAE v6.0 (NCI), original English text.

Peripheral motor neuropathy

Nervous system disorders
  1. G1Mild symptoms; clinical or diagnostic observations only
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by damage or dysfunction of the peripheral motor nerves.

Navigational noteConsider Nervous system disorders: Peripheral sensory neuropathy.

MedDRA code (LLT): 10034580 · CTCAE v6.0 (NCI), original English text.

Peripheral sensory neuropathy

Nervous system disorders
  1. G1Mild symptoms
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by damage or dysfunction of the peripheral sensory nerves.

MedDRA code (LLT): 10034620 · CTCAE v6.0 (NCI), original English text.

Phantom pain

Nervous system disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a sensation of marked discomfort related to a limb or an organ that is removed from or is not physically part of the body.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10056238 · CTCAE v6.0 (NCI), original English text.

Presyncope

Nervous system disorders
  1. G1Not applicable
  2. G2Present (e.g., near fainting)
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an episode of lightheadedness and dizziness which may precede an episode of syncope.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10036653 · CTCAE v6.0 (NCI), original English text.

Pyramidal tract syndrome

Nervous system disorders
  1. G1Mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include an increase in the muscle tone in the lower extremities, hyperreflexia, positive Babinski and a decrease in fine motor coordination.

MedDRA code (LLT): 10063636 · CTCAE v6.0 (NCI), original English text.

Radiculitis

Nervous system disorders
  1. G1Mild symptoms
  2. G2Moderate symptoms; medical intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root.

MedDRA code (LLT): 10061928 · CTCAE v6.0 (NCI), original English text.

Recurrent laryngeal nerve palsy

Nervous system disorders
  1. G1Mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms
  3. G3Severe symptoms; medical intervention indicated (e.g., thyroplasty, vocal cord injection)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by paralysis of the recurrent laryngeal nerve.

MedDRA code (LLT): 10038130 · CTCAE v6.0 (NCI), original English text.

Reversible posterior leukoencephalopathy syndrome

Nervous system disorders
  1. G1Not applicable
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; hospitalization; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences
  5. G5Death
Definition and note

DefinitionA disorder characterized by headaches, mental status changes, visual disturbances, and/or seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. It is an acute or subacute reversible condition. Also known as posterior reversible encephalopathy syndrome (PRES).

MedDRA code (LLT): 10063761 · CTCAE v6.0 (NCI), original English text.

Seizure

Nervous system disorders
  1. G1Brief partial/focal seizure and no loss of consciousness
  2. G2Brief generalized seizure; seizure(s) well controlled by anticonvulsants; infrequent partial/focal motor seizures
  3. G3New onset seizures (partial/focal or generalized); multiple seizures despite medical intervention
  4. G4Life-threatening consequences; prolonged repetitive generalized seizures
  5. G5Death
Definition and note

DefinitionA disorder characterized by a sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin.

MedDRA code (LLT): 10039906 · CTCAE v6.0 (NCI), original English text.

Somnolence

Nervous system disorders
  1. G1Mild but more than usual drowsiness or sleepiness
  2. G2Moderate sedation; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Obtundation or stupor
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by characterized by excessive sleepiness and drowsiness.

MedDRA code (LLT): 10041349 · CTCAE v6.0 (NCI), original English text.

Spasticity

Nervous system disorders
  1. G1Mild or slight increase in muscle tone
  2. G2Moderate increase in muscle tone and increase in resistance through range of motion
  3. G3Severe increase in muscle tone and increase in resistance through range of motion
  4. G4Life-threatening consequences; unable to move active or passive range of motion
  5. G5Death
Definition and note

DefinitionA disorder characterized by increased involuntary muscle tone that affects the regions interfering with voluntary movement. It results in gait, movement, and speech disturbances.

MedDRA code (LLT): 10041416 · CTCAE v6.0 (NCI), original English text.

Spinal cord compression

Nervous system disorders
  1. G1Radiologic findings only
  2. G2Mild or moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by pressure on the spinal cord.

MedDRA code (LLT): 10041549 · CTCAE v6.0 (NCI), original English text.

Stroke

Nervous system disorders
  1. G1Incidental radiographic findings only
  2. G2Mild to moderate neurologic deficit; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe neurologic deficit; hospitalization; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an interruption of blood supply to parts of the brain resulting in neurological damage.

MedDRA code (LLT): 10042244 · CTCAE v6.0 (NCI), original English text.

Syncope

Nervous system disorders
  1. G1Not applicable
  2. G2Not applicable
  3. G3Fainting; orthostatic collapse
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by spontaneous loss of consciousness caused by insufficient blood supply to the brain.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10042772 · CTCAE v6.0 (NCI), original English text.

Tendon reflex decreased

Nervous system disorders
  1. G1Ankle reflex reduced
  2. G2Ankle reflex absent; other reflexes reduced
  3. G3Absence of all reflexes
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by less than normal deep tendon reflexes.

Navigational noteConsider Nervous system disorders: Peripheral motor neuropathy, Peripheral sensory neuropathy.

MedDRA code (LLT): 10043245 · CTCAE v6.0 (NCI), original English text.

Transient ischemic attacks

Nervous system disorders
  1. G1Mild neurologic deficit with or without imaging confirmation
  2. G2Moderate neurologic deficit with or without imaging confirmation
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit.

Navigational noteIf >24 hours, Consider Nervous system disorders: Stroke.

MedDRA code (LLT): 10044391 · CTCAE v6.0 (NCI), original English text.

Tremor

Nervous system disorders
  1. G1Mild symptoms
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by the uncontrolled shaking movement of the whole body or individual parts.

MedDRA code (LLT): 10044565 · CTCAE v6.0 (NCI), original English text.

Trigeminal nerve disorder

Nervous system disorders
  1. G1Mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by dysfunction of the trigeminal nerve (fifth cranial nerve).

MedDRA code (LLT): 10060890 · CTCAE v6.0 (NCI), original English text.

Trochlear nerve disorder

Nervous system disorders
  1. G1Mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by dysfunction of the trochlear nerve (fourth cranial nerve).

MedDRA code (LLT): 10074765 · CTCAE v6.0 (NCI), original English text.

Tumor inflammation-associated neurotoxicity

Nervous system disordersNew in v6.0
  1. G1Headaches associated with fevers; mild worsening of existing neurological clinical signs and symptoms from baseline, resulting in minor functional deficits for which only observation or symptomatic management is needed
  2. G2Moderate changes in the neurological exam from baseline that substantially affect function
  3. G3Severe neurological clinical signs and symptoms that may affect critical cardiorespiratory functions; clinical signs and symptoms of increased intracranial pressure (>20 mmHg) that are responsive to intervention
  4. G4Life-threatening, clinically significant elevated ICP (>20 mmHg) refractory to CSF drainage with no improvement in clinical symptoms in response to CSF drainage, possibly warranting urgent escalation of neurosurgical intervention; clinical signs and symptoms of impending/early herniation; severe medullary dysfunction requiring endotracheal intubation for airway protection and/or mechanical ventilation
  5. G5Death
Definition and note

DefinitionA disorder characterized by localized neurotoxicity related to cellular therapies or other immunotherapies for CNS tumors (TIAN).

MedDRA code (LLT): 10091322 · CTCAE v6.0 (NCI), original English text.

Vagus nerve disorder

Nervous system disorders
  1. G1Mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by dysfunction of the vagus nerve (tenth cranial nerve).

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10061403 · CTCAE v6.0 (NCI), original English text.

Vasovagal reaction

Nervous system disorders
  1. G1Not applicable
  2. G2No management indicated
  3. G3Requires active management
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve.

MedDRA code (LLT): 10047166 · CTCAE v6.0 (NCI), original English text.

From the same authorCódigo OncoCódigo Onco (in Portuguese): Brazilian public health system (SUS) codes for systemic cancer treatment.