Tumor inflammation-associated neurotoxicity
Nervous system disordersNew in v6.0
- G1Headaches associated with fevers; mild worsening of existing neurological clinical signs and symptoms from baseline, resulting in minor functional deficits for which only observation or symptomatic management is needed
- G2Moderate changes in the neurological exam from baseline that substantially affect function
- G3Severe neurological clinical signs and symptoms that may affect critical cardiorespiratory functions; clinical signs and symptoms of increased intracranial pressure (>20 mmHg) that are responsive to intervention
- G4Life-threatening, clinically significant elevated ICP (>20 mmHg) refractory to CSF drainage with no improvement in clinical symptoms in response to CSF drainage, possibly warranting urgent escalation of neurosurgical intervention; clinical signs and symptoms of impending/early herniation; severe medullary dysfunction requiring endotracheal intubation for airway protection and/or mechanical ventilation
- G5Death
Definition and note
DefinitionA disorder characterized by localized neurotoxicity related to cellular therapies or other immunotherapies for CNS tumors (TIAN).
MedDRA code (LLT): 10091322 · CTCAE v6.0 (NCI), original English text.