Immune effector cell-associated neurotoxicity syndrome
Nervous system disordersNew in v6.0
- G1Mild symptoms; Immune Effector Cell-Associated Encephalopathy (ICE) score 7 - 9; Cornell Assessment of Pediatric Delirium (CAPD) score 1 - 8 AND awakens spontaneously
- G2Moderate symptoms; ICE score 3 - 6; CAPD score 1 - 8 AND awakens to voice; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
- G3Severe symptoms; ICE score 0 - 2; CAPD score >=9 AND awakens only to tactile stimulus; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
- G4Life-threatening consequences; urgent intervention indicated
- G5Death
Definition and note
DefinitionA disorder characterized by a pathologic process involving the central nervous system following any immune therapy that results in the activation or engagement of endogenous or infused T cells and/or other immune effector cells. Symptoms or signs can be progressive and may include aphasia, altered level of consciousness, impairment of cognitive skills, motor weakness, seizures, and cerebral edema.
MedDRA code (LLT): 10083347 · CTCAE v6.0 (NCI), original English text.