Serum sickness
- G1Clinical or diagnostic observations only; intervention not indicated
- G2Moderate arthralgia; fever, rash, urticaria, antihistamines indicated
- G3Severe arthralgia or arthritis; extensive rash; steroids or IV fluids indicated
- G4Life-threatening consequences; pressor or ventilatory support indicated
- G5Death
Definition and note
DefinitionA disorder characterized by a delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty-one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest marked discomfort and dyspnea.
MedDRA code (LLT): 10040400 · CTCAE v6.0 (NCI), original English text.