Osteoporosis
- G1Adult: Radiologic evidence of osteoporosis or Bone Mineral Density (BMD) t-score -1 to -2.5 (osteopenia); Pediatric: BMD z score of <=-2.0 and no history of significant fractures
- G2Adult: BMD t-score <-2.5; loss of height <2 cm; therapy to improve BMD indicated; limiting instrumental ADL; Pediatric: BMD z-score <=-2.0 and significant fracture history (defined as a long bone fracture of the lower extremity, vertebral compression, 2 or more long bone fractures of the upper extremities); mild/moderate impact on age-appropriate normal daily activity
- G3Adult: Loss of height >=2 cm; hospitalization indicated; limiting self-care ADL; Pediatric: Severe impact on age-appropriate normal daily activity
- G4Not applicable
- G5Not applicable
Definition and note
DefinitionA disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence.
MedDRA code (LLT): 10031282 · CTCAE v6.0 (NCI), original English text.