CTCAE RápidoAdverse event grades · CTCAE v6.0
Código Onco

Musculoskeletal and connective tissue disorders

The 44 CTCAE v6.0 adverse events in Musculoskeletal and connective tissue disorders, with grades 1 to 5.

Abdominal soft tissue necrosis

Musculoskeletal and connective tissue disorders
  1. G1Not applicable
  2. G2Local wound care; medical intervention indicated (e.g., dressings or topical medications)
  3. G3Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a necrotic process occurring in the soft tissues of the abdominal wall.

MedDRA code (LLT): 10065775 · CTCAE v6.0 (NCI), original English text.

Arthralgia

Musculoskeletal and connective tissue disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a sensation of marked discomfort in a joint.

Navigational noteReport Inflammatory arthritis as Musculoskeletal and connective tissue disorder - Other, specify (Inflammatory arthritis).

MedDRA code (LLT): 10003239 · CTCAE v6.0 (NCI), original English text.

Arthritis

Musculoskeletal and connective tissue disorders
  1. G1Mild pain with inflammation, erythema, or joint swelling
  2. G2Moderate pain associated with signs of inflammation, erythema, or joint swelling; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain associated with signs of inflammation, erythema, or joint swelling; irreversible joint damage; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by inflammation involving a joint.

Navigational noteReport Inflammatory arthritis as Musculoskeletal and connective tissue disorder - Other, specify (Inflammatory arthritis).

MedDRA code (LLT): 10003246 · CTCAE v6.0 (NCI), original English text.

Back pain

Musculoskeletal and connective tissue disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a sensation of marked discomfort in the back region.

Navigational noteConsider Injury, poisoning and procedural complications: Infusion related reaction; Record final diagnosis/cause once determined.

MedDRA code (LLT): 10003988 · CTCAE v6.0 (NCI), original English text.

Bone pain

Musculoskeletal and connective tissue disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a sensation of marked discomfort in the bones.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10006002 · CTCAE v6.0 (NCI), original English text.

Buttock pain

Musculoskeletal and connective tissue disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a sensation of marked discomfort in the buttocks.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10048677 · CTCAE v6.0 (NCI), original English text.

Chest wall necrosis

Musculoskeletal and connective tissue disorders
  1. G1Not applicable
  2. G2Local wound care; medical intervention indicated (e.g., dressings or topical medications)
  3. G3Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a necrotic process occurring in the soft tissues of the chest wall including breast.

MedDRA code (LLT): 10048831 · CTCAE v6.0 (NCI), original English text.

Chest wall pain

Musculoskeletal and connective tissue disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a sensation of marked discomfort in the chest wall.

Navigational noteReport Inflammatory costochondritis as Musculoskeletal and connective tissue disorder - Other, specify (Inflammatory costochondritis). Record final diagnosis/cause once determined.

MedDRA code (LLT): 10008496 · CTCAE v6.0 (NCI), original English text.

Exostosis

Musculoskeletal and connective tissue disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; elective operative intervention indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by non-neoplastic overgrowth of bone.

MedDRA code (LLT): 10015688 · CTCAE v6.0 (NCI), original English text.

Fibrosis deep connective tissue

Musculoskeletal and connective tissue disorders
  1. G1Mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)
  2. G2Moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Generalized; associated with signs or symptoms of impaired breathing or feeding
  5. G5Death
Definition and note

DefinitionA disorder characterized by fibrotic degeneration of the deep connective tissues.

MedDRA code (LLT): 10065799 · CTCAE v6.0 (NCI), original English text.

Flank pain

Musculoskeletal and connective tissue disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a sensation of marked discomfort on the lateral side of the body in the region below the ribs and above the hip.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10016750 · CTCAE v6.0 (NCI), original English text.

Generalized muscle weakness

Musculoskeletal and connective tissue disorders
  1. G1Symptomatic; perceived by patient but not evident on physical exam
  2. G2Symptomatic; evident on physical exam; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a reduction in the strength of muscles in multiple anatomic sites.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10062572 · CTCAE v6.0 (NCI), original English text.

Growth accelerated

Musculoskeletal and connective tissue disorders
  1. G1Not applicable
  2. G2>=+2 SD (standard deviation) above mid parental height or target height
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by greater growth than expected for age.

MedDRA code (LLT): 10018746 · CTCAE v6.0 (NCI), original English text.

Growth suppression

Musculoskeletal and connective tissue disorders
  1. G1Reduction in growth velocity by 10 - 29% ideally measured over the period of a year
  2. G2Reduction in growth velocity by 30 - 49% ideally measured over the period of a year or 0 - 49% reduction in growth from the baseline growth curve
  3. G3Reduction in growth velocity of >=50% ideally measured over the period of a year
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by stature that is smaller than normal as expected for age.

MedDRA code (LLT): 10018761 · CTCAE v6.0 (NCI), original English text.

Head soft tissue necrosis

Musculoskeletal and connective tissue disorders
  1. G1Not applicable
  2. G2Local wound care; medical intervention indicated (e.g., dressings or topical medications)
  3. G3Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a necrotic process occurring in the soft tissues of the head.

Navigational noteConsider Respiratory, thoracic and mediastinal disorders: Sinus disorder, Grade 4.

MedDRA code (LLT): 10065779 · CTCAE v6.0 (NCI), original English text.

Joint effusion

Musculoskeletal and connective tissue disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; invasive intervention indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by excessive fluid in a joint, usually as a result of joint inflammation.

MedDRA code (LLT): 10023215 · CTCAE v6.0 (NCI), original English text.

Joint range of motion decreased

Musculoskeletal and connective tissue disorders
  1. G1<=25% loss of ROM (range of motion); decreased ROM limiting athletic activity
  2. G2>25 - 50% decrease in ROM; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3>50% decrease in ROM; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a decrease in joint flexibility of any joint.

Navigational noteReport Inflammatory arthritis as Musculoskeletal and connective tissue disorder - Other, specify (Inflammatory arthritis).

MedDRA code (LLT): 10048706 · CTCAE v6.0 (NCI), original English text.

Joint range of motion decreased cervical spine

Musculoskeletal and connective tissue disorders
  1. G1Mild restriction of rotation or flexion between 60 - 70 degrees
  2. G2Rotation <60 degrees to right or left; <60 degrees of flexion
  3. G3Ankylosed/fused over multiple segments with no C-spine rotation
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a decrease in flexibility of a cervical spine joint.

Navigational noteReport Inflammatory arthritis as Musculoskeletal and connective tissue disorder - Other, specify (Inflammatory arthritis).

MedDRA code (LLT): 10065796 · CTCAE v6.0 (NCI), original English text.

Joint range of motion decreased lumbar spine

Musculoskeletal and connective tissue disorders
  1. G1Stiffness; difficulty bending to the floor to pick up a very light object but able to do athletic activity
  2. G2Pain with range of motion (ROM) in lumbar spine; requires a reaching aid to pick up a very light object from the floor
  3. G3<50% lumbar spine flexion; associated with symptoms of ankylosis or fused over multiple segments with no L-spine flexion (e.g., unable to reach to floor to pick up a very light object)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a decrease in flexibility of a lumbar spine joint.

Navigational noteReport Inflammatory arthritis as Musculoskeletal and connective tissue disorder - Other, specify (Inflammatory arthritis).

MedDRA code (LLT): 10065800 · CTCAE v6.0 (NCI), original English text.

Kyphosis

Musculoskeletal and connective tissue disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate accentuation; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe accentuation; operative intervention indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an abnormal increase in the curvature of the thoracic portion of the spine.

MedDRA code (LLT): 10023509 · CTCAE v6.0 (NCI), original English text.

Lordosis

Musculoskeletal and connective tissue disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate accentuation; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe accentuation; operative intervention indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an abnormal increase in the curvature of the lumbar portion of the spine.

MedDRA code (LLT): 10024842 · CTCAE v6.0 (NCI), original English text.

Muscle cramp

Musculoskeletal and connective tissue disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by marked cramping sensation originating from a muscle or group of muscles.

Navigational noteSynonym: Muscle spasm

MedDRA code (LLT): 10028294 · CTCAE v6.0 (NCI), original English text.

Muscle weakness lower limb

Musculoskeletal and connective tissue disorders
  1. G1Symptomatic; perceived by patient but not evident on physical exam
  2. G2Symptomatic; evident on physical exam; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a reduction in the strength of the lower limb muscles.

Navigational noteConsider Musculoskeletal and connective tissue disorders: Myositis; Immune system disorders: Immune system disorders - Other, specify; Injury, poisoning and procedural complications: Fall.

MedDRA code (LLT): 10065776 · CTCAE v6.0 (NCI), original English text.

Muscle weakness trunk

Musculoskeletal and connective tissue disorders
  1. G1Symptomatic; perceived by patient but not evident on physical exam
  2. G2Symptomatic; evident on physical exam; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a reduction in the strength of the trunk muscles.

Navigational noteConsider Musculoskeletal and connective tissue disorders: Myositis; Immune system disorders: Immune system disorders - Other, specify; Injury, poisoning and procedural complications: Fall.

MedDRA code (LLT): 10065795 · CTCAE v6.0 (NCI), original English text.

Muscle weakness upper limb

Musculoskeletal and connective tissue disorders
  1. G1Symptomatic; perceived by patient but not evident on physical exam
  2. G2Symptomatic; evident on physical exam; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a reduction in the strength of the upper limb muscles.

Navigational noteConsider Musculoskeletal and connective tissue disorders: Myositis; Immune system disorders: Immune system disorders - Other, specify; Injury, poisoning and procedural complications: Fall.

MedDRA code (LLT): 10065895 · CTCAE v6.0 (NCI), original English text.

Musculoskeletal and connective tissue disorder - Other, specify

Musculoskeletal and connective tissue disorders
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

MedDRA code (LLT): 10028395 · CTCAE v6.0 (NCI), original English text.

Musculoskeletal deformity

Musculoskeletal and connective tissue disorders
  1. G1Cosmetically and functionally insignificant hypoplasia
  2. G2Deformity, hypoplasia, or asymmetry able to be remediated by prosthesis (e.g., shoe insert) or covered by clothing
  3. G3Significant deformity, hypoplasia, or asymmetry, unable to be remediated by prosthesis or covered by clothing; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an abnormality of the musculoskeletal system.

MedDRA code (LLT): 10065783 · CTCAE v6.0 (NCI), original English text.

Myalgia

Musculoskeletal and connective tissue disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by marked discomfort sensation originating from a muscle or group of muscles.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10028411 · CTCAE v6.0 (NCI), original English text.

Myositis

Musculoskeletal and connective tissue disorders
  1. G1Mild pain
  2. G2Moderate pain associated with weakness; pain limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Pain associated with severe weakness; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by inflammation involving the skeletal muscles.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10028653 · CTCAE v6.0 (NCI), original English text.

Neck pain

Musculoskeletal and connective tissue disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a sensation of marked discomfort in the neck area.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10028836 · CTCAE v6.0 (NCI), original English text.

Neck soft tissue necrosis

Musculoskeletal and connective tissue disorders
  1. G1Not applicable
  2. G2Local wound care; medical intervention indicated (e.g., dressings or topical medications)
  3. G3Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a necrotic process occurring in the soft tissues of the neck.

MedDRA code (LLT): 10065781 · CTCAE v6.0 (NCI), original English text.

Osteonecrosis

Musculoskeletal and connective tissue disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic; medical intervention indicated (e.g., analgesics or bisphosphonates); limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; elective operative intervention indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure.

MedDRA code (LLT): 10031264 · CTCAE v6.0 (NCI), original English text.

Osteonecrosis of jaw

Musculoskeletal and connective tissue disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic; medical intervention indicated (e.g., topical agents); limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; elective operative intervention indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a necrotic process occurring in the bone of the mandible.

MedDRA code (LLT): 10064658 · CTCAE v6.0 (NCI), original English text.

Osteoporosis

Musculoskeletal and connective tissue disorders
  1. G1Adult: Radiologic evidence of osteoporosis or Bone Mineral Density (BMD) t-score -1 to -2.5 (osteopenia); Pediatric: BMD z score of <=-2.0 and no history of significant fractures
  2. G2Adult: BMD t-score <-2.5; loss of height <2 cm; therapy to improve BMD indicated; limiting instrumental ADL; Pediatric: BMD z-score <=-2.0 and significant fracture history (defined as a long bone fracture of the lower extremity, vertebral compression, 2 or more long bone fractures of the upper extremities); mild/moderate impact on age-appropriate normal daily activity
  3. G3Adult: Loss of height >=2 cm; hospitalization indicated; limiting self-care ADL; Pediatric: Severe impact on age-appropriate normal daily activity
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence.

MedDRA code (LLT): 10031282 · CTCAE v6.0 (NCI), original English text.

Pain in extremity

Musculoskeletal and connective tissue disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a sensation of marked discomfort in the upper or lower extremities.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10033425 · CTCAE v6.0 (NCI), original English text.

Pelvic soft tissue necrosis

Musculoskeletal and connective tissue disorders
  1. G1Not applicable
  2. G2Local wound care; medical intervention indicated (e.g., dressings or topical medications)
  3. G3Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a necrotic process occurring in the soft tissues of the pelvis.

MedDRA code (LLT): 10065793 · CTCAE v6.0 (NCI), original English text.

Rhabdomyolysis

Musculoskeletal and connective tissue disorders
  1. G1Asymptomatic, intervention not indicated; laboratory findings only
  2. G2Non-urgent intervention indicated
  3. G3Symptomatic, urgent intervention indicated
  4. G4Life-threatening consequences; dialysis
  5. G5Death
Definition and note

DefinitionA disorder characterized by the breakdown of muscle tissue resulting in the release of muscle fiber contents into the bloodstream.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10039020 · CTCAE v6.0 (NCI), original English text.

Rotator cuff injury

Musculoskeletal and connective tissue disorders
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental AD or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an injury of the rotator cuff.

MedDRA code (LLT): 10039226 · CTCAE v6.0 (NCI), original English text.

Scoliosis

Musculoskeletal and connective tissue disorders
  1. G1<20 degrees; clinically undetectable
  2. G2>20 - 45 degrees; visible by forward flexion; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3>45 degrees; scapular prominence in forward flexion; operative intervention indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a lateral curvature of the spine.

MedDRA code (LLT): 10039722 · CTCAE v6.0 (NCI), original English text.

Soft tissue necrosis lower limb

Musculoskeletal and connective tissue disorders
  1. G1Not applicable
  2. G2Local wound care; medical intervention indicated (e.g., dressings or topical medications)
  3. G3Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a necrotic process occurring in the soft tissues of the lower extremity.

MedDRA code (LLT): 10065777 · CTCAE v6.0 (NCI), original English text.

Soft tissue necrosis upper limb

Musculoskeletal and connective tissue disorders
  1. G1Not applicable
  2. G2Local wound care; medical intervention indicated (e.g., dressings or topical medications)
  3. G3Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a necrotic process occurring in the soft tissues of the upper extremity.

MedDRA code (LLT): 10065778 · CTCAE v6.0 (NCI), original English text.

Superficial soft tissue fibrosis

Musculoskeletal and connective tissue disorders
  1. G1Mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)
  2. G2Moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Generalized; associated with signs or symptoms of impaired breathing or feeding
  5. G5Death
Definition and note

DefinitionA disorder characterized by fibrotic degeneration of the superficial soft tissues.

MedDRA code (LLT): 10065798 · CTCAE v6.0 (NCI), original English text.

Trismus

Musculoskeletal and connective tissue disorders
  1. G1Decreased ROM (range of motion) without impaired eating
  2. G2Decreased ROM requiring small bites, soft foods or purees
  3. G3Decreased ROM with inability to adequately aliment or hydrate orally
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by lack of ability to open the mouth fully due to a decrease in the range of motion of the muscles of mastication.

MedDRA code (LLT): 10044684 · CTCAE v6.0 (NCI), original English text.

Unequal limb length

Musculoskeletal and connective tissue disorders
  1. G1Mild length discrepancy <2 cm
  2. G2Moderate length discrepancy 2 - 5 cm; shoe lift indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe length discrepancy >5 cm; operative intervention indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a discrepancy between the lengths of the lower or upper extremities.

MedDRA code (LLT): 10065738 · CTCAE v6.0 (NCI), original English text.

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