Differentiation syndrome
- G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
- G2Moderate; minimal, local, or noninvasive intervention indicated; limiting age appropriate instrumental ADL
- G3Severe or medically significant but not immediately life-threatening; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
- G4Life-threatening consequences; urgent intervention indicated
- G5Death
Definition and note
DefinitionA potentially fatal complication of treatment in certain molecular subgroups of leukemia characterized by fever, rash, dyspnea and/or hypoxia, pulmonary infiltrates, peripheral edema with rapid weight gain, pleuropericardial effusion, acute renal failure, disseminated intravascular coagulation (DIC), bone pain and/or hypotension.
MedDRA code (LLT): 10080638 · CTCAE v6.0 (NCI), original English text.