CTCAE RápidoAdverse event grades · CTCAE v6.0
Código Onco

Respiratory, thoracic and mediastinal disorders

The 61 CTCAE v6.0 adverse events in Respiratory, thoracic and mediastinal disorders, with grades 1 to 5.

Adult respiratory distress syndrome

Respiratory, thoracic and mediastinal disorders
  1. G1Not applicable
  2. G2Not applicable
  3. G3Present with radiologic findings; intubation not indicated
  4. G4Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery.

Navigational noteConsider Respiratory, thoracic and mediastinal disorders: Pneumonitis.

MedDRA code (LLT): 10001409 · CTCAE v6.0 (NCI), original English text.

Allergic rhinitis

Respiratory, thoracic and mediastinal disorders
  1. G1Mild symptoms; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea and itching.

MedDRA code (LLT): 10001723 · CTCAE v6.0 (NCI), original English text.

Aphonia

Respiratory, thoracic and mediastinal disorders
  1. G1Not applicable
  2. G2Not applicable
  3. G3Voicelessness; unable to speak
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic).

MedDRA code (LLT): 10002953 · CTCAE v6.0 (NCI), original English text.

Apnea

Respiratory, thoracic and mediastinal disorders
  1. G1Not applicable
  2. G2Not applicable
  3. G3Present; medical intervention indicated
  4. G4Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by cessation of breathing.

MedDRA code (LLT): 10002972 · CTCAE v6.0 (NCI), original English text.

Aspiration

Respiratory, thoracic and mediastinal disorders
  1. G1Clinical or diagnostic observations only; intervention not indicated
  2. G2Altered eating habits; coughing or choking episodes after eating or swallowing; medical intervention indicated (e.g., suction or oxygen)
  3. G3Dyspnea and pneumonia symptoms (e.g., aspiration pneumonia); hospitalization indicated; unable to aliment orally
  4. G4Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by inhalation of solids or liquids into the lungs.

MedDRA code (LLT): 10003504 · CTCAE v6.0 (NCI), original English text.

Atelectasis

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic (e.g., dyspnea, cough); medical intervention indicated (e.g., chest physiotherapy, suctioning); bronchoscopic suctioning
  3. G3Supplemental oxygen indicated; hospitalization or elective operative intervention indicated (e.g., stent, laser)
  4. G4Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by the collapse of part or the entire lung.

MedDRA code (LLT): 10003598 · CTCAE v6.0 (NCI), original English text.

Bronchial fistula

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic
  2. G2Symptomatic, invasive intervention not indicated
  3. G3Invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an abnormal communication between the bronchus and another organ or anatomic site.

MedDRA code (LLT): 10006437 · CTCAE v6.0 (NCI), original English text.

Bronchial obstruction

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic (e.g., mild wheezing); endoscopic evaluation indicated; radiographic evidence of atelectasis/lobar collapse; medical management indicated (e.g., steroids, bronchodilators)
  3. G3Shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement)
  4. G4Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by blockage of a bronchus passage, most often by bronchial secretions and exudates.

MedDRA code (LLT): 10006440 · CTCAE v6.0 (NCI), original English text.

Bronchial stricture

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic (e.g., rhonchi or wheezing) but without respiratory distress; medical intervention indicated (e.g., steroids, bronchodilators)
  3. G3Shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement)
  4. G4Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a narrowing of the bronchial tube.

MedDRA code (LLT): 10063524 · CTCAE v6.0 (NCI), original English text.

Bronchopleural fistula

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic
  2. G2Symptomatic, invasive intervention not indicated
  3. G3Hospitalization; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an abnormal communication between a bronchus and the pleural cavity.

MedDRA code (LLT): 10053481 · CTCAE v6.0 (NCI), original English text.

Bronchopulmonary hemorrhage

Respiratory, thoracic and mediastinal disorders
  1. G1Mild symptoms; intervention not indicated
  2. G2Moderate symptoms; invasive intervention not indicated
  3. G3Hospitalization
  4. G4Life-threatening consequences; intubation or urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by bleeding from the bronchial wall and/or lung parenchyma.

MedDRA code (LLT): 10065746 · CTCAE v6.0 (NCI), original English text.

Bronchospasm

Respiratory, thoracic and mediastinal disorders
  1. G1Mild symptoms; intervention not indicated
  2. G2Symptomatic; medical intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Supplemental oxygen indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a sudden contraction of the smooth muscles of the bronchial wall or narrowing of the airway. May be manifested as wheezing.

MedDRA code (LLT): 10006482 · CTCAE v6.0 (NCI), original English text.

Chylothorax

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic; medical intervention indicated (e.g., fat-restricted diet); thoracentesis or tube drainage indicated
  3. G3Severe symptoms; elective operative intervention indicated
  4. G4Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by milky pleural effusion (abnormal collection of fluid) resulting from accumulation of lymph fluid in the pleural cavity.

MedDRA code (LLT): 10051228 · CTCAE v6.0 (NCI), original English text.

Cough

Respiratory, thoracic and mediastinal disorders
  1. G1Mild symptoms; nonprescription intervention indicated
  2. G2Moderate symptoms, medical intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10011224 · CTCAE v6.0 (NCI), original English text.

Dyspnea

Respiratory, thoracic and mediastinal disorders
  1. G1Shortness of breath with moderate exertion
  2. G2Shortness of breath with minimal exertion; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Shortness of breath at rest; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an uncomfortable sensation of difficulty breathing.

Navigational noteConsider Cardiac disorders: Heart failure; Record final diagnosis/cause once determined.

MedDRA code (LLT): 10013963 · CTCAE v6.0 (NCI), original English text.

Epistaxis

Respiratory, thoracic and mediastinal disorders
  1. G1Mild symptoms; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated (e.g., nasal packing, cauterization; topical vasoconstrictors)
  3. G3Transfusion; invasive intervention indicated (e.g., hemostasis of bleeding site)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by bleeding from the nose.

MedDRA code (LLT): 10015090 · CTCAE v6.0 (NCI), original English text.

Hiccups

Respiratory, thoracic and mediastinal disorders
  1. G1Mild symptoms; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; interfering with sleep; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm.

MedDRA code (LLT): 10020039 · CTCAE v6.0 (NCI), original English text.

Hoarseness

Respiratory, thoracic and mediastinal disorders
  1. G1Mild or intermittent voice change; fully understandable; self-resolves
  2. G2Moderate or persistent voice changes; may require occasional repetition but understandable on telephone; medical evaluation indicated
  3. G3Severe voice changes including predominantly whispered speech
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by harsh and raspy voice arising from or spreading to the larynx.

MedDRA code (LLT): 10020201 · CTCAE v6.0 (NCI), original English text.

Hypoxia

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic decrease in oxygen saturation <LLN
  2. G2Decreased oxygen saturation with exercise (e.g., pulse oximeter <88%); intermittent supplemental oxygen
  3. G3Decreased oxygen saturation at rest (e.g., pulse oximeter <88% or PaO2 <=55 mmHg); continuous supplemental oxygen
  4. G4Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
  5. G5Death
Definition and note

DefinitionA disorder characterized by a decrease in the level of oxygen in the body.

Navigational noteConsider Respiratory, thoracic and mediastinal disorders: Dyspnea, Pneumonitis; Record final diagnosis/cause once determined.

MedDRA code (LLT): 10021143 · CTCAE v6.0 (NCI), original English text.

Laryngeal edema

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic; medical intervention indicated (e.g., dexamethasone, epinephrine, antihistamines)
  3. G3Stridor; respiratory distress; hospitalization indicated
  4. G4Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
  5. G5Death
Definition and note

DefinitionA disorder characterized by swelling due to an excessive accumulation of fluid in the larynx.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10023838 · CTCAE v6.0 (NCI), original English text.

Laryngeal fistula

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic
  2. G2Symptomatic, invasive intervention not indicated
  3. G3Invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an abnormal communication between the larynx and another organ or anatomic site.

MedDRA code (LLT): 10065786 · CTCAE v6.0 (NCI), original English text.

Laryngeal hemorrhage

Respiratory, thoracic and mediastinal disorders
  1. G1Mild cough or trace hemoptysis; laryngoscopic findings
  2. G2Moderate symptoms; intervention indicated
  3. G3Hospitalization
  4. G4Life-threatening consequences; urgent intervention indicated (e.g., tracheotomy or intubation)
  5. G5Death
Definition and note

DefinitionA disorder characterized by bleeding from the larynx.

MedDRA code (LLT): 10065759 · CTCAE v6.0 (NCI), original English text.

Laryngeal inflammation

Respiratory, thoracic and mediastinal disorders
  1. G1Mild sore throat; raspy voice
  2. G2Moderate sore throat; analgesics indicated
  3. G3Severe throat pain; endoscopic intervention indicated
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an inflammation involving the larynx.

MedDRA code (LLT): 10065735 · CTCAE v6.0 (NCI), original English text.

Laryngeal mucositis

Respiratory, thoracic and mediastinal disorders
  1. G1Endoscopic findings only; mild discomfort with normal intake
  2. G2Moderate pain, analgesics indicated; altered oral intake; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; severely altered eating/swallowing; medical intervention indicated
  4. G4Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
  5. G5Death
Definition and note

DefinitionA disorder characterized by ulceration or inflammation involving the mucous membrane of the larynx.

MedDRA code (LLT): 10065880 · CTCAE v6.0 (NCI), original English text.

Laryngeal obstruction

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Stridor; endoscopic intervention indicated (e.g., stent, laser); limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by blockage of the laryngeal airway.

MedDRA code (LLT): 10059639 · CTCAE v6.0 (NCI), original English text.

Laryngeal stenosis

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Stridor; endoscopic intervention indicated (e.g., stent, laser); limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a narrowing of the laryngeal airway.

MedDRA code (LLT): 10023862 · CTCAE v6.0 (NCI), original English text.

Laryngopharyngeal dysesthesia

Respiratory, thoracic and mediastinal disorders
  1. G1Mild symptoms; no anxiety; intervention not indicated
  2. G2Moderate symptoms; mild anxiety, but no dyspnea; short duration of observation and/or anxiolytic indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; dyspnea and swallowing difficulty; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences
  5. G5Death
Definition and note

DefinitionA disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx.

MedDRA code (LLT): 10062667 · CTCAE v6.0 (NCI), original English text.

Laryngospasm

Respiratory, thoracic and mediastinal disorders
  1. G1Not applicable
  2. G2Transient episode; intervention not indicated
  3. G3Recurrent episodes; noninvasive intervention indicated (e.g., breathing technique, pressure point massage)
  4. G4Persistent or severe episodes associated with syncope; urgent intervention indicated (e.g., fiberoptic laryngoscopy, intubation, botox injection)
  5. G5Death
Definition and note

DefinitionA disorder characterized by paroxysmal spasmodic muscular contraction of the vocal cords.

MedDRA code (LLT): 10023891 · CTCAE v6.0 (NCI), original English text.

Mediastinal hemorrhage

Respiratory, thoracic and mediastinal disorders
  1. G1Mild symptoms; intervention not indicated; radiologic evidence only
  2. G2Moderate symptoms; intervention indicated
  3. G3Hospitalization
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by bleeding from the mediastinum.

MedDRA code (LLT): 10056356 · CTCAE v6.0 (NCI), original English text.

Nasal congestion

Respiratory, thoracic and mediastinal disorders
  1. G1Mild symptoms; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Associated with bloody nasal discharge or epistaxis
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by obstruction of the nasal passage due to mucosal edema.

MedDRA code (LLT): 10028735 · CTCAE v6.0 (NCI), original English text.

Oropharyngeal pain

Respiratory, thoracic and mediastinal disorders
  1. G1Mild pain
  2. G2Moderate pain; altered oral intake; non-narcotics initiated; topical analgesics initiated
  3. G3Severe pain; severely altered eating/swallowing; narcotics initiated; requires parenteral nutrition
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a sensation of marked discomfort in the oropharynx or pain on swallowing.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10068319 · CTCAE v6.0 (NCI), original English text.

Pharyngeal fistula

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic
  2. G2Symptomatic, invasive intervention not indicated
  3. G3Invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an abnormal communication between the pharynx and another organ or anatomic site.

MedDRA code (LLT): 10034825 · CTCAE v6.0 (NCI), original English text.

Pharyngeal hemorrhage

Respiratory, thoracic and mediastinal disorders
  1. G1Mild symptoms; intervention not indicated
  2. G2Moderate symptoms; intervention indicated
  3. G3Hospitalization
  4. G4Life-threatening consequences; intubation or urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by bleeding from the pharynx.

MedDRA code (LLT): 10055315 · CTCAE v6.0 (NCI), original English text.

Pharyngeal mucositis

Respiratory, thoracic and mediastinal disorders
  1. G1Endoscopic findings only; minimal symptoms with normal oral intake; mild pain but analgesics not indicated
  2. G2Moderate pain, analgesics indicated; altered oral intake; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; unable to adequately aliment or hydrate orally; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by ulceration or inflammation involving the mucous membrane of the pharynx.

MedDRA code (LLT): 10065881 · CTCAE v6.0 (NCI), original English text.

Pharyngeal necrosis

Respiratory, thoracic and mediastinal disorders
  1. G1Not applicable
  2. G2Not applicable
  3. G3Inability to aliment adequately by GI tract; invasive intervention indicated; tube feeding or TPN indicated
  4. G4Life-threatening consequences; urgent operative intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a necrotic process occurring in the pharynx.

MedDRA code (LLT): 10065706 · CTCAE v6.0 (NCI), original English text.

Pharyngeal stenosis

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Stridor; endoscopic intervention indicated (e.g., stent, laser); limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
  5. G5Death
Definition and note

DefinitionA disorder characterized by a narrowing of the pharyngeal airway.

MedDRA code (LLT): 10050028 · CTCAE v6.0 (NCI), original English text.

Pharyngolaryngeal pain

Respiratory, thoracic and mediastinal disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a sensation of marked discomfort in the pharyngolaryngeal region.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10034844 · CTCAE v6.0 (NCI), original English text.

Pleural effusion

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic; intervention indicated (e.g., diuretics or therapeutic thoracentesis)
  3. G3Symptomatic with respiratory distress and hypoxia; operative intervention including chest tube or pleurodesis indicated
  4. G4Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10035598 · CTCAE v6.0 (NCI), original English text.

Pleural hemorrhage

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic; mild hemorrhage confirmed by thoracentesis
  2. G2Symptomatic or associated with pneumothorax; chest tube drainage indicated
  3. G3>1000 ml of blood evacuated; persistent bleeding (150-200 ml/hr for 2 - 4 hr); persistent transfusion indicated; elective operative intervention indicated; hospitalization
  4. G4Life-threatening consequences; intubation or urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by bleeding from the pleural cavity.

MedDRA code (LLT): 10055319 · CTCAE v6.0 (NCI), original English text.

Pleuritic pain

Respiratory, thoracic and mediastinal disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a sensation of marked discomfort in the pleura.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10035623 · CTCAE v6.0 (NCI), original English text.

Pneumonitis

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic; medical intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; oxygen indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
  5. G5Death
Definition and note

DefinitionA disorder characterized by inflammation focally or diffusely affecting the lung parenchyma.

MedDRA code (LLT): 10035742 · CTCAE v6.0 (NCI), original English text.

Pneumothorax

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic; intervention indicated
  3. G3Sclerosis and/or operative intervention indicated; hospitalization indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by abnormal presence of air in the pleural cavity resulting in the collapse of the lung.

MedDRA code (LLT): 10035759 · CTCAE v6.0 (NCI), original English text.

Postnasal drip

Respiratory, thoracic and mediastinal disorders
  1. G1Mild symptoms; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by excessive mucous secretion in the back of the nasal cavity or throat, causing sore throat and/or coughing.

MedDRA code (LLT): 10036402 · CTCAE v6.0 (NCI), original English text.

Productive cough

Respiratory, thoracic and mediastinal disorders
  1. G1Occasional/minimal production of sputum with cough
  2. G2Moderate sputum production; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Persistent or copious production of sputum; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by expectorated secretions upon coughing.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10036790 · CTCAE v6.0 (NCI), original English text.

Pulmonary edema

Respiratory, thoracic and mediastinal disorders
  1. G1Radiologic findings only; minimal dyspnea on exertion
  2. G2Moderate dyspnea on exertion; medical intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe dyspnea or dyspnea at rest; oxygen indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening respiratory compromise; urgent intervention or intubation with ventilatory support indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by accumulation of fluid in the lung tissues that causes a disturbance of the gas exchange that may lead to respiratory failure.

Navigational noteUnless there is a clear non-cardiac cause, please record this event as Cardiac disorders: Heart failure. Record final diagnosis/cause once determined.

MedDRA code (LLT): 10037375 · CTCAE v6.0 (NCI), original English text.

Pulmonary fibrosis

Respiratory, thoracic and mediastinal disorders
  1. G1Radiologic pulmonary fibrosis <25% of lung volume associated with hypoxia
  2. G2Evidence of pulmonary hypertension; radiographic pulmonary fibrosis 25 - 50% associated with hypoxia
  3. G3Severe hypoxia; evidence of right-sided heart failure; radiographic pulmonary fibrosis >50 - 75%
  4. G4Life-threatening consequences (e.g., hemodynamic/pulmonary complications); intubation with ventilatory support indicated; radiographic pulmonary fibrosis >75% with severe honeycombing
  5. G5Death
Definition and note

DefinitionA disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure or right heart failure.

MedDRA code (LLT): 10037383 · CTCAE v6.0 (NCI), original English text.

Pulmonary fistula

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic
  2. G2Symptomatic, invasive intervention not indicated
  3. G3Invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an abnormal communication between the lung and another organ or anatomic site.

MedDRA code (LLT): 10065873 · CTCAE v6.0 (NCI), original English text.

Pulmonary hypertension

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic; radiographic, physical, or diagnostic findings
  2. G2Symptomatic; requiring medical intervention
  3. G3Severe symptoms, associated with hypoxia, right heart failure; oxygen indicated
  4. G4Life-threatening airway consequences; urgent intervention indicated (e.g., tracheotomy or intubation)
  5. G5Death
Definition and note

DefinitionA disorder characterized by an increase in pressure within the pulmonary circulation due to lung or heart disorder.

MedDRA code (LLT): 10037400 · CTCAE v6.0 (NCI), original English text.

Respiratory failure

Respiratory, thoracic and mediastinal disorders
  1. G1Not applicable
  2. G2Not applicable
  3. G3Not applicable
  4. G4Life-threatening consequences; urgent intervention, intubation, or ventilatory support indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by impaired gas exchange by the respiratory system resulting in hypoxia and a decrease in oxygenation of the tissues that may be associated with an increase in arterial levels of carbon dioxide.

Navigational noteConsider Respiratory, thoracic and mediastinal disorders: Pneumonitis.

MedDRA code (LLT): 10038695 · CTCAE v6.0 (NCI), original English text.

Respiratory, thoracic and mediastinal disorders - Other, specify

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

MedDRA code (LLT): 10038738 · CTCAE v6.0 (NCI), original English text.

Rhinorrhea

Respiratory, thoracic and mediastinal disorders
  1. G1Present
  2. G2Not applicable
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by excessive mucous secretions draining from the nose.

MedDRA code (LLT): 10039100 · CTCAE v6.0 (NCI), original English text.

Sinus disorder

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic mucosal crusting; blood-tinged secretions
  2. G2Symptomatic stenosis or edema/narrowing interfering with airflow; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Stenosis with significant nasal obstruction; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Necrosis of soft tissue or bone; urgent operative intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by involvement of the paranasal sinuses.

MedDRA code (LLT): 10062244 · CTCAE v6.0 (NCI), original English text.

Sinus pain

Respiratory, thoracic and mediastinal disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a sensation of marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10040747 · CTCAE v6.0 (NCI), original English text.

Sleep apnea

Respiratory, thoracic and mediastinal disorders
  1. G1Snoring and nocturnal sleep arousal without apneic periods
  2. G2Moderate apnea and oxygen desaturation; excessive daytime sleepiness; medical evaluation indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Oxygen desaturation; associated with pulmonary hypertension; medical intervention indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Cardiovascular or neuropsychiatric symptoms; urgent operative intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by cessation of breathing for short periods during sleep.

MedDRA code (LLT): 10040975 · CTCAE v6.0 (NCI), original English text.

Sneezing

Respiratory, thoracic and mediastinal disorders
  1. G1Mild symptoms; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by the involuntary expulsion of air from the nose.

MedDRA code (LLT): 10041232 · CTCAE v6.0 (NCI), original English text.

Sore throat

Respiratory, thoracic and mediastinal disorders
  1. G1Mild pain
  2. G2Moderate pain; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; limiting ability to swallow; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by marked discomfort in the throat.

MedDRA code (LLT): 10041367 · CTCAE v6.0 (NCI), original English text.

Stridor

Respiratory, thoracic and mediastinal disorders
  1. G1Not applicable
  2. G2Not applicable
  3. G3Respiratory distress; medical intervention indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
  5. G5Death
Definition and note

DefinitionA disorder characterized by a high pitched breathing sound due to laryngeal or upper airway obstruction.

MedDRA code (LLT): 10042241 · CTCAE v6.0 (NCI), original English text.

Tracheal fistula

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic
  2. G2Symptomatic, invasive intervention not indicated
  3. G3Invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an abnormal communication between the trachea and another organ or anatomic site.

MedDRA code (LLT): 10065787 · CTCAE v6.0 (NCI), original English text.

Tracheal mucositis

Respiratory, thoracic and mediastinal disorders
  1. G1Endoscopic findings only; minimal hemoptysis, pain, or respiratory symptoms
  2. G2Moderate symptoms; medical intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe pain; hemorrhage or respiratory symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an inflammation or ulceration involving the mucous membrane of the trachea.

MedDRA code (LLT): 10065900 · CTCAE v6.0 (NCI), original English text.

Tracheal stenosis

Respiratory, thoracic and mediastinal disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Stridor or respiratory distress; invasive intervention indicated (e.g., stent, laser); limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
  5. G5Death
Definition and note

DefinitionA disorder characterized by a narrowing of the trachea.

MedDRA code (LLT): 10050816 · CTCAE v6.0 (NCI), original English text.

Voice alteration

Respiratory, thoracic and mediastinal disorders
  1. G1Mild or intermittent change from normal voice
  2. G2Moderate or persistent change from normal voice; still understandable
  3. G3Severe voice changes including predominantly whispered speech; may require frequent repetition or face-to-face contact for understandability; may require assistive technology
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a change in the sound and/or speed of the voice.

MedDRA code (LLT): 10047681 · CTCAE v6.0 (NCI), original English text.

From the same authorCódigo OncoCódigo Onco (in Portuguese): Brazilian public health system (SUS) codes for systemic cancer treatment.