Ovarian function insufficiency
Reproductive system and breast disordersNew in v6.0
- G1Intermittent/irregular menses for 3 consecutive months with basal FSH levels >25 IU/L but less than postmenopausal range
- G2Amenorrhea for 3 consecutive months with basal FSH levels >40 IU/L or in the postmenopausal range
- G3Not applicable
- G4Not applicable
- G5Not applicable
Definition and note
DefinitionA disorder characterized by the development of oligomenorrhea or amenorrhea for at least 3 consecutive months and serum follicle-stimulating hormone (FSH) levels in the menopausal range before age 40. Symptoms of estrogen deficiency may include hot flashes, night sweats, mood swings, and vaginal dryness. Laboratory findings include elevated serum FSH. Other supportive laboratory findings include decreased serum estradiol and anti-Mullerian hormone (AMH) levels.
MedDRA code (LLT): 10033169 · CTCAE v6.0 (NCI), original English text.